pinch tummies, not pennies

prescription

Disposable, ready for use, prefilled Single-Dose Syringe containing 250 mcg per 0.5 mL of ganirelix acetate, closed with a rubber piston that does not contain latex. Each prefilled syringe is affixed with a 29 gauge and 0.5 inch needle.

Ganirelix acetate injection is supplied in a single dose, sterile, prefilled syringe and is intended for SUBCUTANEOUS administration only.

dosage and administration

After initiating FSH therapy on Day 2 or 3 of the cycle, ganirelix acetate injection 250 mcg may be administered subcutaneously once daily during the mid to late portion of the follicular phase. By taking advantage of endogenous pituitary FSH secretion, the requirement for exogenously administered FSH may be reduced. Treatment with ganirelix acetate should be continued daily until the day of hCG administration. When a sufficient number of follicles of adequate size are present, as assessed by ultrasound, final maturation of follicles is induced by administering hCG. The administration of hCG should be withheld in cases where the ovaries are abnormally enlarged on the last day of FSH therapy to reduce the chance of developing OHSS (Ovarian Hyperstimulation Syndrome).

what are the uses of ganirelix?

Ganirelix Acetate Injection is indicated for the inhibition of premature LH surges in women undergoing controlled ovarian hyperstimulation.

what is an antagonist?

Antagonists block the effects of a natural hormone, called gonadotropin- releasing hormone (GnRH). GnRH controls the secretion of another hormone, called luteinizing hormone (LH), which induces ovulation during the menstrual cycle.

what can you expect with an antagonist

Ganirelix acetate injection should be prescribed by physicians who are experienced in fertility treatment.

injection directions

Ganirelix Acetate is injected subcutaneously-or into the fatty tissue under your skin. The primary sites for injection are your abdomen – 2 inches on either side of the navel, and your upper, outer-thigh where the skin is loose.

1. Ganirelix acetate injection is supplied in a single dose, sterile, prefilled syringe and is intended for SUBCUTANEOUS administration only.
2. Wash hands thoroughly with soap and water.
3. The most convenient sites for SUBCUTANEOUS injection are in the abdomen around the navel or upper thigh.
4. The injection site should be swabbed with a disinfectant to remove any surface bacteria. Clean about two inches around the point where the needle will be inserted and let the disinfectant dry for at least one minute before proceeding.
5. With syringe held upward, remove needle cover.
6. Pinch up a large area of skin between the finger and thumb. Vary the injection site a little with each injection.
7. The needle should be inserted at the base of the pinched-up skin at an angle of 45–90° to the skin surface.
8. When the needle is correctly positioned, it will be difficult to draw back on the plunger. If any blood is drawn into the syringe, the needle tip has penetrated a vein or artery. If this happens, withdraw the needle slightly and reposition the needle without removing it from the skin. Alternatively, remove the needle and use a new, sterile, prefilled syringe. Cover the injection site with a swab containing disinfectant and apply pressure; the site should stop bleeding within one or two minutes.
9. Once the needle is correctly placed, depress the plunger slowly and steadily, so the solution is correctly injected and the skin is not damaged.
10. Pull the syringe out quickly and apply pressure to the site with a swab containing disinfectant.
11. Use the sterile, prefilled syringe only once. Discard the unused portion and dispose of it properly.

storage directions

Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F). See USP Controlled Room Temperature.

needle disposal directions

The FDA recommends that used needles and other sharps be immediately placed in FDA-cleared sharps disposal containers. FDA-cleared sharps disposal containers are generally available through pharmacies, medical supply companies, health care providers, and online.

Cetrorelix

Cetrorelix Acetate for Injection blocks the effects of a natural hormone, called gonadotropin-releasing hormone (GnRH). GnRH controls the secretion of another hormone, called luteinizing hormone (LH), which induces ovulation during the menstrual cycle. During hormone treatment for ovarian stimulation, premature ovulation may lead to eggs that are not suitable for fertilization. Cetrorelix acetate blocks such undesirable premature ovulation.

prescription

Cetrorelix Acetate for Injection 0.25 mg is a sterile lyophilized powder intended for subcutaneous injection after reconstitution with Sterile Water for Injection, USP (pH 5 to 8), that comes supplied in a 1 mL prefilled syringe. Each vial of Cetrorelix Acetate for Injection 0.25 mg contains 0.26-0.27 mg cetrorelix acetate, equivalent to 0.25 mg cetrorelix, and 54.80 mg mannitol.

dosage and administration

Ovarian stimulation therapy with gonadotropins (FSH, hMG) is started on cycle Day 2 or 3. The dose of gonadotropins should be adjusted according to individual response. Cetrorelix Acetate for Injection 0.25 mg may be administered subcutaneously once daily during the early- to mid-follicular phase. Cetrorelix Acetate for Injection 0.25 mg is administered on either stimulation day 5 (morning or evening) or day 6 (morning) and continued daily until the day of hCG administration. When assessment by ultrasound shows a sufficient number of follicles of adequate size, hCG is administered to induce ovulation and final maturation of the oocytes. No hCG should be administered if the ovaries show an excessive response to the

what are the uses of cetrorelix?

Cetrorelix Acetate for Injection is used to prevent premature ovulation during controlled ovarian stimulation.

what is an antagonist?

Antagonists block the effects of a natural hormone, called gonadotropin- releasing hormone (GnRH). GnRH controls the secretion of another hormone, called luteinizing hormone (LH), which induces ovulation during the menstrual cycle.

what can you expect with an antagonist

Cetrorelix Acetate for Injection should be prescribed by physicians who are experienced in fertility treatment.

injection directions

Directions for using Cetrorelix Acetate for Injection 0.25 mg with the enclosed needles and prefilled syringe:

1. Wash hands thoroughly with soap and water.
2. Flip off the plastic cover of the vial and wipe the aluminum ring and the rubber stopper with an alcohol swab.
3. Twist the injection needle with the yellow mark (20-gauge) on the prefilled syringe.
4. Push the needle through the center of the rubber stopper of the vial and slowly inject the solvent into the vial.
5. Leaving the syringe in the vial, gently swirl the vial until the solution is clear and without residues. Avoid forming bubbles.
6. Draw the total contents of the vial into the syringe. If necessary, invert the vial and pull back the needle as far as needed to withdraw the entire contents of the vial.
7. Replace the needle with the yellow mark by the injection needle with the grey mark (27-gauge).
8. Invert the syringe and push the plunger until all air bubbles have been expelled.
9. Choose an injection site in the lower abdominal area, preferably around, but staying at least one inch away from the navel. Choose a different injection site each day to minimize local irritation. Use a second alcohol swab to clean the skin at the injection site and allow alcohol to dry. Gently pinch up the skin surrounding the site of injection.
10. Inject the prescribed dose as directed by your doctor, nurse or pharmacist.
11. Use the syringe and needles only once. Dispose of the syringe and needles properly after use. If available, use a medical waste container for disposal.

storage directions

Store refrigerated 2° to 8ºC (36° to 46ºF). Store the packaged tray in the outer carton in order to protect from light. Discard unused portion.

needle disposal directions

The FDA recommends that used needles and other sharps be immediately placed in FDA-cleared sharps disposal containers. FDA-cleared sharps di posal containers are generally available through pharmacies, medical supply companies, health care providers, and online.